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PEA shields in opposition to bacterial infection via innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA in a dose of 0.1 mg/kg overall body weight extended survival fee and decreased neuro-inflammation in an aged murine bacterial meningitis design, within the absence of antibiotics [42].The exogenous administration

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Central administration of palmitoylethanolamide minimizes hyperalgesia in mice by using inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J PharmacolA clinical illustration of hyperalgesia may be an amputee that's unable to utilize a prosthesis thanks to tenderness overlying the stump.Not one of the RCTs talked about higher than

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